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Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer.

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作者单位: National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. [1] Department of Obstetrics and Gynecology, Division of Gynecological Oncology and Clinical Research Center, Hannover Medical School, Hannover, Germany. [2] Department of Medical Oncology, Hospital del Mar, CIBERONC, Barcelona, Spain. [3] Rigshospitalet, Copenhagen, Denmark. [4] Ramon y Cajal University Hospital, Madrid, Spain. [5] Vall d'Hebron Institute of Oncology, Barcelona, Spain. [6] Department of Medical Oncology, Institute Curie, Paris, France. [7] Department of Medical Oncology, Biomedical Health Research Institute INCLIVA, University of Valencia, Valencia and CIBERONC, Institute of Health Carlos III, Madrid, Spain. [8] Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain. [9] Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany. [10] Departments of Clinical Research Unit and Medical Oncology, Centre François Baclesse, Caen, France. [11] Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland. [12] Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany. wolfgang.jacob@roche.com. [13] Pharma Research and Early Development (pRED), Roche Innovation Center Welwyn, Welwyn Garden City, UK. [14] A4P Consulting Ltd, Sandwich, UK. [15] Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany. [16]
DOI 10.1007/s10637-018-0562-4
PMID 29349598
发布时间 2024-07-02
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