Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model.

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作者： Akiko,Saito ^[1] ; Akio,Ooki ^[2] ; Takashi,Nakamura ^[3] ; Shoko,Onodera ^[3] ; Kamichika,Hayashi ^[4] ; Daigo,Hasegawa ^[4] ; Takahito,Okudaira ^[4] ; Katsuhito,Watanabe ^[4] ; Hiroshi,Kato ^[4] ; Takeshi,Onda ^[4] ; Akira,Watanabe ^[4] ; Kenjiro,Kosaki ^[5] ; Ken,Nishimura ^[6] ; Manami,Ohtaka ^[7] ; Mahito,Nakanishi ^[7] ; Teruo,Sakamoto ^[2] ; Akira,Yamaguchi ^[8] ; Kenji,Sueishi ^[2] ; Toshifumi,Azuma ^[3]

作者单位： Department of Biochemistry, Tokyo Dental College, Tokyo, Japan. ayokoyama@tdc.ac.jp. ^[1] Department of Orthodontics, Tokyo Dental College, Tokyo, Japan. ^[2] Department of Biochemistry, Tokyo Dental College, Tokyo, Japan. ^[3] Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan. ^[4] Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan. ^[5] Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. ^[6] Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan. ^[7] Oral Health Science Center, Tokyo Dental College, Tokyo, Japan. ^[8]

关键词 CRISPR/Cas Cleidocranial dysplasia Osteoblasts Osteogenesis RUNX2 iPSCs