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Compartmentalization of HP1 Proteins in Pluripotency Acquisition and Maintenance.

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第一作者： Nur Zafirah,Zaidan

第一单位： Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Genetics Training Program, University of Wisconsin-Madison, Madison, WI 53715, USA.

作者： Nur Zafirah,Zaidan ^[1] ; Kolin J,Walker ^[2] ; Jaime E,Brown ^[2] ; Leah V,Schaffer ^[3] ; Mark,Scalf ^[3] ; Michael R,Shortreed ^[3] ; Gopal,Iyer ^[4] ; Lloyd M,Smith ^[3] ; Rupa,Sridharan ^[5]

作者单位： Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Genetics Training Program, University of Wisconsin-Madison, Madison, WI 53715, USA. ^[1] Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA. ^[2] Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53715, USA. ^[3] Department of Human Oncology, University of Wisconsin-Madison, Madison, WI 53715, USA. ^[4] Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53715, USA. Electronic address: rsridharan2@wisc.edu. ^[5]

关键词 Dppa4 H3.3 H3K9M HP1α knockout HP1β knockout HP1γ knockout Senp7 iPSC pluripotency reprogramming

医学主题词动物(Animals);染色质(Chromatin);染色体蛋白质类, 非组蛋白(Chromosomal Proteins, Non-Histone);内肽酶类(Endopeptidases);外切核糖核酸酶类(Exoribonucleases);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);组蛋白类(Histones);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);多蛋白复合物(Multiprotein Complexes);核蛋白质类(Nuclear Proteins);八聚体转录因子3(Octamer Transcription Factor-3);蛋白质类(Proteins);阻遏蛋白质类(Repressor Proteins);核糖核酸酶类(Ribonucleases);转录因子(Transcription Factors)

DOI 10.1016/j.stemcr.2017.12.016

PMID 29358085

发布时间 2021-12-04

基金项目

R01 GM113033/GM/NIGMS NIH HHS/United States R01 GM114292/GM/NIGMS NIH HHS/United States T32 GM008349/GM/NIGMS NIH HHS/United States

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