A Comparative Pharmacokinetic Study by UHPLC-MS/MS of Main Active Compounds after Oral Administration of Zushima-Gancao Extract in Normal and Adjuvant-Induced Arthritis Rats.

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第一作者： Jinjun,Shan

第一单位： Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. jshan@njucm.edu.cn.

作者： Jinjun,Shan ^[1] ; Wenjuan,Qian ^[2] ; Linxiu,Peng ^[3] ; Lianghui,Chen ^[4] ; An,Kang ^[5] ; Tong,Xie ^[6] ; Liuqing,Di ^[7]

作者单位： Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. jshan@njucm.edu.cn. ^[1] State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. 20161325@njucm.edu.cn. ^[2] State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. penglinxiu1016@hotmail.com. ^[3] State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. chenlhnow@126.com. ^[4] Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. kanga@njucm.edu. ^[5] State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. kanga@njucm.edu. ^[6] Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. sunnyxyl1021@163.com. ^[7] Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com. ^[8] State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com. ^[9] Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com. ^[10]

关键词 UHPLC-MS/MS Zushima-Gancao extract pharmacokinetics rheumatoid arthritis