Efficacy and safety of artemisinin-based combination therapy and chloroquine with concomitant primaquine to treat Plasmodium vivax malaria in Brazil: an open label randomized clinical trial.

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第一作者： André,Daher

第一单位： Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. andredaher@gmail.com.

作者： André,Daher ^[1] ; Dhelio,Pereira ^[2] ; Marcus V G,Lacerda ^[3] ; Márcia A A,Alexandre ^[4] ; Cristiana T,Nascimento ^[5] ; Júlio Castro,Alves de Lima E Silva ^[6] ; Mauro,Tada ^[7] ; Rosilene,Ruffato ^[7] ; Ivan,Maia ^[7] ; Tereza Cristina,Dos Santos ^[8] ; Paola,Marchesini ^[4] ; Ana Carolina,Santelli ^[4] ; David G,Lalloo ^[9]

作者单位： Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. andredaher@gmail.com. ^[1] Vice-presidency of Research and Reference Laboratories, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. andredaher@gmail.com. ^[2] Liverpool School of Tropical Medicine, Liverpool, UK. andredaher@gmail.com. ^[3] Tropical Medicine Research Center of Rondonia (CEPEM), Porto Velho, Brazil. ^[4] Federal University of Rondonia (UNIR), Porto Velho, Brazil. ^[5] Research Institute Leônidas & Maria Deane, FIOCRUZ, Manaus, Brazil. ^[6] Tropical Medicine Foundation Dr Heitor Vieira Dourado, Manaus, Brazil. ^[7] National Institute of Infectious Disease, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. ^[8] Vice-presidency of Research and Reference Laboratories, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. ^[9] Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. ^[10] National Malaria Control Programme, Ministry of Health, Brasília, Brazil. ^[11] Liverpool School of Tropical Medicine, Liverpool, UK. ^[12]

关键词 ACT Antimalarial treatment Artemether Artemisinin-based combination therapy Artesunate Chloroquine Clinical trial Lumefantrine Malaria Mefloquine Plasmodium vivax Primaquine