第一单位：
Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.;Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
作者：
Sebastian,Mueller [1]
;
Thomas,Engleitner [2]
;
Roman,Maresch [2]
;
Magdalena,Zukowska [1]
;
Sebastian,Lange [1]
;
Thorsten,Kaltenbacher [2]
;
Björn,Konukiewitz [3]
;
Rupert,Öllinger [1]
;
Maximilian,Zwiebel [4]
;
Alex,Strong [5]
;
Hsi-Yu,Yen [6]
;
Ruby,Banerjee [5]
;
Sandra,Louzada [5]
;
Beiyuan,Fu [5]
;
Barbara,Seidler [1]
;
Juliana,Götzfried [4]
;
Kathleen,Schuck [4]
;
Zonera,Hassan [4]
;
Andreas,Arbeiter [4]
;
Nina,Schönhuber [1]
;
Sabine,Klein [1]
;
Christian,Veltkamp [1]
;
Mathias,Friedrich [5]
;
Lena,Rad [4]
;
Maxim,Barenboim [7]
;
Christoph,Ziegenhain [8]
;
Julia,Hess [9]
;
Oliver M,Dovey [5]
;
Stefan,Eser [4]
;
Swati,Parekh [8]
;
Fernando,Constantino-Casas [10]
;
Jorge,de la Rosa [11]
;
Marta I,Sierra [12]
;
Mario,Fraga [13]
;
Julia,Mayerle [14]
;
Günter,Klöppel [3]
;
Juan,Cadiñanos [15]
;
Pentao,Liu [5]
;
George,Vassiliou [5]
;
Wilko,Weichert [16]
;
Katja,Steiger [17]
;
Wolfgang,Enard [8]
;
Roland M,Schmid [7]
;
Fengtang,Yang [5]
;
Kristian,Unger [9]
;
Günter,Schneider [7]
;
Ignacio,Varela [18]
;
Allan,Bradley [5]
;
Dieter,Saur [2]
;
Roland,Rad [2]
作者单位：
Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.;Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
[1]
Center for Translational Cancer Research (TranslaTUM), Technische Universität München, 81675 Munich, Germany.;Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
[2]
Institute of Pathology, Technische Universität München, 81675 Munich, Germany.
[3]
Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
[4]
The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
[5]
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.;Comparative Experimental Pathology, Technische Universität München, 81675 Munich, Germany.
[6]
Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
[7]
Anthropology & Human Genomics, Department of Biology II, Ludwig-Maximilians Universität, 82152 Martinsried, Germany.
[8]
Helmholtz Zentrum München, Research Unit Radiation Cytogenetics, 85764 Neuherberg, Germany.
[9]
Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
[10]
The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.;Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA), 33193 Oviedo, Spain.;Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
[11]
Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, 33011 Oviedo, Spain.
[12]
Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, 33011 Oviedo, Spain.;Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo, 33940 El Entrego, Spain.
[13]
Medizinische Klinik und Poliklinik II, Klinikum der LMU München-Grosshadern, 81377 Munich, Germany.
[14]
The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.;Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA), 33193 Oviedo, Spain.
[15]
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.;Institute of Pathology, Technische Universität München, 81675 Munich, Germany.
[16]
Institute of Pathology, Technische Universität München, 81675 Munich, Germany.;Comparative Experimental Pathology, Technische Universität München, 81675 Munich, Germany.
[17]
Instituto de Biomedicina y Biotecnología de Cantabria (UC-CSIC), 39012 Santander, Spain.
[18]
医学主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);等位基因(Alleles);动物(Animals);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞周期蛋白质类(Cell Cycle Proteins);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);疾病恶化(Disease Progression);进化, 分子(Evolution, Molecular);女(雌)性(Female);基因剂量(Gene Dosage);基因, myc(Genes, myc);基因, p53(Genes, p53);人类(Humans);男(雄)性(Male);小鼠(Mice);突变(Mutation);p52亚基NF-κB(NF-kappa B p52 Subunit);肿瘤转移(Neoplasm Metastasis);核蛋白质类(Nuclear Proteins);胰腺肿瘤(Pancreatic Neoplasms);表型(Phenotype);磷蛋白类(Phosphoproteins);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));转录因子(Transcription Factors);转化生长因子β1(Transforming Growth Factor beta1)
DOI
10.1038/nature25459
PMID
29364867
发布时间
2025-05-30
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