Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor.
第一作者:
Song,Yang
第一单位:
Department of Neurosurgery, Suqian First Hospital, Suqian, Jiangsu, China. melatoninsah@yeah.net.
作者:
医学主题词
动物(Animals);细胞凋亡(Apoptosis);脑(Brain);脑损伤(Brain Injuries);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);男(雄)性(Male);褪黑激素(Melatonin);小鼠, 近交C57BL(Mice, Inbred C57BL);微RNAs(MicroRNAs);神经生长因子(Nerve Growth Factor);神经元(Neurons);神经保护药(Neuroprotective Agents);启动区, 遗传(Promoter Regions, Genetic);蛛网膜下腔出血(Subarachnoid Hemorrhage);转录, 遗传(Transcription, Genetic);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1038/s41419-017-0155-8
PMID
29367587
发布时间
2019-06-13
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