EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition.

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作者： Barry,Jutten ^[1] ; Tom G,Keulers ^[1] ; Hanneke J M,Peeters ^[1] ; Marco B E,Schaaf ^[1] ; Kim G M,Savelkouls ^[1] ; Inge,Compter ^[2] ; Ruud,Clarijs ^[3] ; Olaf E M G,Schijns ^[4] ; Linda,Ackermans ^[4] ; Onno P M,Teernstra ^[4] ; Marijke I,Zonneveld ^[1] ; Resi M E,Colaris ^[3] ; Ludwig,Dubois ^[1] ; Marc A,Vooijs ^[1] ; Johan,Bussink ^[5] ; Julio,Sotelo ^[6] ; Jan,Theys ^[1] ; Guido,Lammering ^[1] ; Kasper M A,Rouschop ^[7]

作者单位： a Department of Radiotherapy, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+ , Maastricht , The Netherlands. ^[1] g Department of Radiation Oncology (MAASTRO Clinic), GROW School for Oncology and Developmental Biology , Maastricht University Medical Centre+ , The Netherlands. ^[2] b Department of Clincial Pathology , Zuyderland MC , Sittard-Geleen , The Netherlands. ^[3] c Department of Neurosurgery , Maastricht University Medical Centre. ^[4] d Department of Radiation Oncology , Radboud University Medical Center , Nijmegen , The Netherlands. ^[5] e Neuroimmunology and Neuro-Oncology Unit, National Institute of Neurology and Neurosurgery , Mexico City , Mexico. ^[6] f Heinrich- Heine University Duesseldorf , Germany. ^[7]

关键词 Autophagy EGFR EGFRvIII chloroquine glioblastoma hypoxia metabolic stress radiotherapy starvation