Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes.

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作者： Junhua,Zhao ^[1] ; Guliang,Wang ^[1] ; Imee M,Del Mundo ^[1] ; Jennifer A,McKinney ^[1] ; Xiuli,Lu ^[1] ; Albino,Bacolla ^[1] ; Stephen B,Boulware ^[1] ; Changsheng,Zhang ^[2] ; Haihua,Zhang ^[3] ; Pengyu,Ren ^[2] ; Catherine H,Freudenreich ^[3] ; Karen M,Vasquez ^[4]

作者单位： Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USA. ^[1] Department of Biomedical Engineering, The University of Texas at Austin, 107 W Dean Keeton Street, Austin, TX 78712, USA. ^[2] Department of Biology, Tufts University, 200 Boston Avenue, Suite 4700, Medford, MA 02155, USA. ^[3] Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USA. Electronic address: karen.vasquez@austin.utexas.edu. ^[4]

关键词 DNA repair DNA structure H-DNA chromosome translocation mutation hotspot nuclease structural simulation