Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer.

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作者： Rasmi R,Mishra ^[1] ; Nevin,Belder ^[1] ; Suhail A,Ansari ^[1] ; Merve,Kayhan ^[1] ; Hilal,Bal ^[1] ; Umar,Raza ^[1] ; Pelin G,Ersan ^[1] ; Ünal M,Tokat ^[1] ; Erol,Eyüpoğlu ^[1] ; Özge,Saatci ^[1] ; Pouria,Jandaghi ^[2] ; Stefan,Wiemann ^[3] ; Ayşegül,Üner ^[4] ; Caglar,Cekic ^[5] ; Yasser,Riazalhosseini ^[1] ; Özgür,Şahin ^[2]

作者单位： Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey. ^[1] Department of Human Genetics, McGill University, Montreal, Quebec, Canada. ^[2] McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada. ^[3] Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[4] Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. ^[5] Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey. sahinozgur@gmail.com. ^[6] National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey. ^[7]