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Reduced pathogenicity of fructose-1,6-bisphosphatase deficient Leishmania donovani and its use as an attenuated strain to induce protective immunogenicity.

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第一作者： Savita,Saini

第一单位： Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, India; Division of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Indian Council of Medical Research, Patna, Bihar, India.

作者： Savita,Saini ^[1] ; Ayan Kumar,Ghosh ^[2] ; Sushmita,Das ^[3] ; Ruby,Singh ^[2] ; Kumar,Abhishek ^[2] ; Sudha,Verma ^[2] ; Ajay,Kumar ^[2] ; Abhishek,Mandal ^[2] ; Bidyut,Purkait ^[2] ; Kislay Kumar,Sinha ^[4] ; Pradeep,Das ^[5]

作者单位： Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, India; Division of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Indian Council of Medical Research, Patna, Bihar, India. ^[1] Division of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Indian Council of Medical Research, Patna, Bihar, India. ^[2] Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India. ^[3] Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, India. ^[4] Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, India; Division of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Indian Council of Medical Research, Patna, Bihar, India. Electronic address: drpradeep.das@gmail.com. ^[5]

关键词 Fructose 1–6, bisphosphatase Gluconeogenesis Leishmania donovani null mutant Live attenuated vaccine