第一单位：
Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, OX3 9DS, UK.;Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
作者：
Yiyan,Zheng [1]
;
Ritika,Sethi [2]
;
Lingegowda S,Mangala [3]
;
Charlotte,Taylor [1]
;
Juliet,Goldsmith [1]
;
Ming,Wang [1]
;
Kenta,Masuda [1]
;
Eli M,Carrami [1]
;
David,Mannion [1]
;
Fabrizio,Miranda [1]
;
Sandra,Herrero-Gonzalez [1]
;
Karin,Hellner [1]
;
Fiona,Chen [1]
;
Abdulkhaliq,Alsaadi [1]
;
Ashwag,Albukhari [4]
;
Donatien Chedom,Fotso [1]
;
Christopher,Yau [5]
;
Dahai,Jiang [3]
;
Sunila,Pradeep [6]
;
Cristian,Rodriguez-Aguayo [7]
;
Gabriel,Lopez-Berestein [7]
;
Stefan,Knapp [8]
;
Nathanael S,Gray [9]
;
Leticia,Campo [10]
;
Kevin A,Myers [10]
;
Sunanda,Dhar [11]
;
David,Ferguson [12]
;
Robert C,Bast [13]
;
Anil K,Sood [3]
;
Frank,von Delft [14]
;
Ahmed Ashour,Ahmed [15]
作者单位：
Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, OX3 9DS, UK.;Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
[1]
Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
[2]
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.;Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
[3]
Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, OX3 9DS, UK.;Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK.;Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia.
[4]
Wellcome Trust Centre for Human Genetics and NIHR Biomedical Research Centre, Roosevelt Drive, Oxford, OX3 7BN, UK.;Department of Statistics, 1 South Parks Road, Oxford, OX1 3TG, UK.
[5]
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
[6]
Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.;Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[7]
Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.;Goethe-University Frankfurt, Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, Riedberg Campus, Frankfurt am Main, 60438, Germany.
[8]
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.;Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
[9]
Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.
[10]
Department of Histopathology, Oxford University Hospitals, Oxford, OX3 9DU, UK.
[11]
Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford, Oxford University Hospitals, Oxford, OX3 9DU, UK.
[12]
Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
[13]
Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.;Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0QX, UK.;Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa.
[14]
Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, OX3 9DS, UK. ahmed.ahmed@obs-gyn.ox.ac.uk.;Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK. ahmed.ahmed@obs-gyn.ox.ac.uk.
[15]
医学主题词
动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);小鼠(Mice);小鼠, 裸(Mice, Nude);显微镜检查, 共焦(Microscopy, Confocal);显微镜检查, 荧光(Microscopy, Fluorescence);微管(Microtubules);分子动力学模拟(Molecular Dynamics Simulation);分子靶向治疗(Molecular Targeted Therapy);肿瘤移植(Neoplasm Transplantation);神经组织蛋白质类(Nerve Tissue Proteins);卵巢肿瘤(Ovarian Neoplasms);紫杉酚(Paclitaxel);磷酰化(Phosphorylation);蛋白质多聚化(Protein Multimerization);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);RNA, 小分子干扰(RNA, Small Interfering);微管蛋白调节因子(Tubulin Modulators)
DOI
10.1038/s41467-017-02811-7
PMID
29396402
发布时间
2025-05-30
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