Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis.

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作者： T,Bonfiglio ^[1] ; G,Olivero ^[1] ; M,Vergassola ^[1] ; L,Di Cesare Mannelli ^[2] ; A,Pacini ^[3] ; F,Iannuzzi ^[4] ; M,Summa ^[5] ; R,Bertorelli ^[5] ; M,Feligioni ^[6] ; C,Ghelardini ^[2] ; A,Pittaluga ^[7]

作者单位： Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy. ^[1] Department of Neuroscience, Psychology, Drug Research and Child Health, Neurofarba, Pharmacology and Toxicology Section, University of Florence, Italy. ^[2] Department of Experimental and Clinical Medicine, DMSC, Section of Anatomy and Histology, University of Florence, Italy. ^[3] EBRI-European Brain Research Institute, Rome, Italy. ^[4] D3. PharmaChemistry Line, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy. ^[5] EBRI-European Brain Research Institute, Rome, Italy; Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy. ^[6] Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy; Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 16132, Genoa, Italy. Electronic address: pittalug@difar.unige.it. ^[7]

关键词 Behaviour Enriched environment Experimental autoimmune encephalomyelitis SNARE proteins cAMP glutamate release