Attenuation of Marek's disease virus by codon pair deoptimization of a core gene.

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第一作者： Steven J,Conrad

第一单位： Avian Disease and Oncology Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 4279 East Mount Hope Road, East Lansing, MI 48823, United States.

作者： Steven J,Conrad ^[1] ; Robert F,Silva ^[1] ; Cari J,Hearn ^[2] ; Megan,Climans ^[3] ; John R,Dunn ^[4]

作者单位： Avian Disease and Oncology Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 4279 East Mount Hope Road, East Lansing, MI 48823, United States. ^[1] Avian Disease and Oncology Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 4279 East Mount Hope Road, East Lansing, MI 48823, United States; Michigan State University College of Veterinary Medicine, East Lansing, MI 48824, United States. ^[2] Michigan State University College of Veterinary Medicine, East Lansing, MI 48824, United States. ^[3] Avian Disease and Oncology Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 4279 East Mount Hope Road, East Lansing, MI 48823, United States. Electronic address: john.dunn@ars.usda.gov. ^[4]

关键词 Codon pair bias Codon pair score Deoptimization MDV Marek's disease virus SAVE Synthetic attenuated virus engineering