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首页> Peptides> Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells.

Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells.

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作者： Jordan,Rowlands ^[1] ; Vinicius,Cruzat ^[2] ; Rodrigo,Carlessi ^[3] ; Philip,Newsholme ^[4]

作者单位： School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University Bldg 305, Rm 135 - CHIRI, Kent St, Bentley, WA, 6102, Australia. Electronic address: 17100353@student.curtin.edu.au. ^[1] School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University Bldg 305, Rm 135 - CHIRI, Kent St, Bentley, WA, 6102, Australia. Electronic address: vinicruzat@gmail.com. ^[2] School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University Bldg 305, Rm 135 - CHIRI, Kent St, Bentley, WA, 6102, Australia. Electronic address: rodrigo.carlessi@curtin.edu.au. ^[3] School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University Bldg 305, Rm 135 - CHIRI, Kent St, Bentley, WA, 6102, Australia. Electronic address: philip.newsholme@curtin.edu.au. ^[4]

关键词 BRIN-BD11 beta cells Bioenergetics Diabetes Exendin-4 GLP-1 Insulin Metabolism

主题词动物(Animals);自身分泌性细胞间通讯(Autocrine Communication);糖尿病(Diabetes Mellitus);能量代谢(Energy Metabolism);葡萄糖(Glucose);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);大鼠(Rats);受体, IGF1型(Receptor, IGF Type 1);受体, 胰岛素(Receptor, Insulin);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1016/j.peptides.2017.11.015

PMID 29412813

发布时间 2021-12-04

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