Preparation, characterization, and optimization of auraptene-loaded solid lipid nanoparticles as a natural anti-inflammatory agent: In vivo and in vitro evaluations.

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作者： Sara,Daneshmand ^[1] ; Mahmoud Reza,Jaafari ^[2] ; Jebrail,Movaffagh ^[3] ; Bizhan,Malaekeh-Nikouei ^[4] ; Mehrdad,Iranshahi ^[5] ; Atieh,Seyedian Moghaddam ^[6] ; Zahra,Tayarani Najaran ^[7] ; Shiva,Golmohammadzadeh ^[8]

作者单位： Department of Pharmaceutical nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. ^[1] Department of Pharmaceutical nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. ^[2] Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. ^[3] Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. ^[4] Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. ^[5] Department of Basic Science, Veterinary medicine school, Ferdowsi University of Mashhad, Mashhad, Iran. ^[6] Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. ^[7] Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Golmohamadzadehsh@mums.ac.ir. ^[8]

关键词 Anti-inflammatory Auraptene Response surface method SLN Skin sensitization Solid lipid nanoparticle