Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.

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作者： Jie,Zhang ^[1] ; Ping-Ping,Jia ^[2] ; Qing-Le,Liu ^[3] ; Ming-Hua,Cong ^[4] ; Yun,Gao ^[5] ; Han-Ping,Shi ^[6] ; Wei-Nan,Yu ^[7] ; Ming-Yong,Miao ^[8]

作者单位： Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical University, and Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, China; Department of Biochemistry and Molecular Biology, The College of Basic Medical Sciences, The Second Military Medical University, Shanghai 200433, China. ^[1] Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. ^[2] Department of Hyperbaric Oxygen Therapy, The First Affiliated Hospital of The Second Military Medical University, Changhai Hospital, Shanghai 200433, China. ^[3] National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. ^[4] Department of Biochemistry and Molecular Biology, The College of Basic Medical Sciences, The Second Military Medical University, Shanghai 200433, China. ^[5] Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;. Electronic address: shihp@vip.163.com. ^[6] Department of Endocrinology, Huai'an Hospital Affiliated to Xuzhou Medical University, and Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, China. Electronic address: hayuweinan@163.com. ^[7] Department of Biochemistry and Molecular Biology, The College of Basic Medical Sciences, The Second Military Medical University, Shanghai 200433, China. Electronic address: miaomy@163.com. ^[8]

关键词 BDH1 HeLa OXCT1 PANC-1 cancer ketogenic diet ketone bodies metabolism xenograft