首页> Bioorganic chemistry> A new entry into the portfolio of α-glucosidase inhibitors as potent therapeutics for type 2 diabetes: Design, bioevaluation and one-pot multi-component synthesis of diamine-bridged coumarinyl oxadiazole conjugates.

A new entry into the portfolio of α-glucosidase inhibitors as potent therapeutics for type 2 diabetes: Design, bioevaluation and one-pot multi-component synthesis of diamine-bridged coumarinyl oxadiazole conjugates.

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第一作者： Madiha,Kazmi

第一单位： Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; Department of Chemistry, University of Gujrat, Rawalpindi Sub-campus, Satellite Town, Rawalpindi, Pakistan.

作者： Madiha,Kazmi ^[1] ; Sumera,Zaib ^[2] ; Aliya,Ibrar ^[3] ; Sayyeda Tayyeba,Amjad ^[4] ; Zainab,Shafique ^[4] ; Saifullah,Mehsud ^[5] ; Aamer,Saeed ^[6] ; Jamshed,Iqbal ^[7] ; Imtiaz,Khan ^[8]

作者单位： Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; Department of Chemistry, University of Gujrat, Rawalpindi Sub-campus, Satellite Town, Rawalpindi, Pakistan. ^[1] Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan; Department of Bioinformatics & Biotechnology, International Islamic University, Islamabad 44000, Pakistan. ^[2] Department of Chemistry, Abbottabad University of Science and Technology, Havelian, Abbottabad, Pakistan. Electronic address: aliya@ciit.net.pk. ^[3] Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. ^[4] Department of Pharmaceutical Sciences, Abbottabad University of Science and Technology, Havelian, Abbottabad, Pakistan. ^[5] Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: asaeed@qau.edu.pk. ^[6] Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: drjamshed@ciit.edu.pk. ^[7] Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan; School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom. Electronic address: khani10@cardiff.ac.uk. ^[8]

关键词 Coumarin Drug design Hybridization approach Molecular docking Multi-component reactions Oxadiazoles