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首页> Scientific reports> LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.

LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.

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作者： Kana,Tanabe ^[1] ; Jiaan,Liu ^[2] ; Daiki,Kato ^[1] ; Hitoshi,Kurumizaka ^[3] ; Kenzo,Yamatsugu ^[3] ; Motomu,Kanai ^[1] ; Shigehiro A,Kawashima ^[2]

作者单位： Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. ^[1] JST-ERATO, Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. ^[2] Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan. ^[3] Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. kanai@mol.f.u-tokyo.ac.jp. ^[4] JST-ERATO, Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. kanai@mol.f.u-tokyo.ac.jp. ^[5] Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. skawashima@mol.f.u-tokyo.ac.jp. ^[6] JST-ERATO, Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. skawashima@mol.f.u-tokyo.ac.jp. ^[7]

主题词乙酰化作用(Acetylation);酰化作用(Acylation);酰基转移酶类(Acyltransferases);催化作用(Catalysis);染色质(Chromatin);色谱法, 液相(Chromatography, Liquid);组蛋白类(Histones);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);赖氨酸(Lysine);线粒体蛋白质类(Mitochondrial Proteins);NAD(NAD);核小体(Nucleosomes);蛋白质加工, 转译后(Protein Processing, Post-Translational);抗衰老酶(Sirtuins);串联质谱法(Tandem Mass Spectrometry)

DOI 10.1038/s41598-018-21060-2

PMID 29422688

发布时间 2019-09-30

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Scientific reports

Scientific reports

2018年8卷1期

2656页

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