Design, synthesis and biological evaluation of novel bouchardatine analogs as potential inhibitors of adipogenesis/lipogenesis in 3T3-L1 adipocytes.

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第一作者： Lin,Gao

第一单位： Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangzhou, 510006, China.

作者： Lin,Gao ^[1] ; Zhao,Xu ^[1] ; Yong,Rao ^[2] ; Yu-Ting,Lu ^[1] ; Yu-Tao,Hu ^[1] ; Hong,Yu ^[1] ; Yao-Hao,Xu ^[1] ; Qing-Qing,Song ^[1] ; Ji-Ming,Ye ^[3] ; Zhi-Shu,Huang ^[4]

作者单位： Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangzhou, 510006, China. ^[1] Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangzhou, 510006, China. Electronic address: 13724891401@126.com. ^[2] Molecular Pharmacology for Diabetes Group, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, 3083, Australia. ^[3] Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangzhou, 510006, China. Electronic address: ceshzs@mail.sysu.edu.cn. ^[4]

关键词 3T3-L1 adipocytes Adipogenesis/lipogenesis Bouchardatine derivatives Lipid-lowering Mitosis clonal expansion