Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation.

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作者： Ilda,D'Annessa ^[1] ; Anna,Gandaglia ^[2] ; Elena,Brivio ^[2] ; Gilda,Stefanelli ^[2] ; Angelisa,Frasca ^[3] ; Nicoletta,Landsberger ^[4] ; Daniele,Di Marino ^[5]

作者单位： Istituto di Chimica del Riconoscimento Molecolare, CNR, Milan, Italy. ^[1] San Raffaele Rett Research Unit, San Raffaele Scientific Institute, Milan, Italy. ^[2] Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy. ^[3] San Raffaele Rett Research Unit, San Raffaele Scientific Institute, Milan, Italy; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy. Electronic address: nicoletta.landsberger@unimi.it. ^[4] Department of Informatics, Institute of Computational Science, Università della Svizzera Italiana, Lugano, Switzerland. Electronic address: daniele.di.marino@usi.ch. ^[5]

关键词 DNA binging domain Docking MeCP2 Methyl-CpG-binding protein 2 Molecular dynamics simulation Rett causing mutation Rett syndrome

主题词氨基酸取代(Amino Acid Substitution);DNA(DNA);女(雌)性(Female);人类(Humans);甲基-CpG-结合蛋白质2(Methyl-CpG-Binding Protein 2);分子动力学模拟(Molecular Dynamics Simulation);突变, 误义(Mutation, Missense);Rett综合征(Rett Syndrome)

DOI 10.1016/j.bbagen.2018.02.005

PMID 29428602

发布时间 2018-09-20

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Biochimica et biophysica acta. General subjects

2018年1862卷5期

1180-1189页

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Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation.

Biochimica et biophysica acta. General subjects

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Biochimica et biophysica acta. General subjects

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Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation.

Biochimica et biophysica acta. General subjects

相似文献

Biochimica et biophysica acta. General subjects

相关期刊

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