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首页> Circulation> Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.

Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.

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作者： John R,Giudicessi ^[1] ; Dan M,Roden ^[2] ; Arthur A M,Wilde ^[3] ; Michael J,Ackerman ^[4]

作者单位： Departments of Cardiovascular Medicine and Internal Medicine, Clinician-Investigator Training Program, Mayo Clinic, Rochester, MN (J.R.G). ^[1] Departments of Biomedical Informatics, Medicine, and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.M.R.). ^[2] Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands (A.A.M.W.). ^[3] Departments of Cardiovascular Diseases, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Divisions of Heart Rhythm Services and Pediatric Cardiology, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (M.J.A.) ackerman.michael@mayo.edu. ^[4]

关键词 arrhythmia genetic testing genetic variation long QT syndrome sudden cardiac death

主题词动作电位(Action Potentials);误诊(Diagnostic Errors);疾病遗传易感性(Genetic Predisposition to Disease);基因检测(Genetic Testing);遗传变异(Genetic Variation);心脏传导系统(Heart Conduction System);心率(Heart Rate);人类(Humans);QT延长综合征(Long QT Syndrome);表型(Phenotype);钾通道, 电压门控(Potassium Channels, Voltage-Gated);试验预期值(Predictive Value of Tests);预后(Prognosis);结果可重复性(Reproducibility of Results);危险性评估(Risk Assessment);危险因素(Risk Factors)

DOI 10.1161/CIRCULATIONAHA.117.030142

PMID 29431662

发布时间 2020-12-29

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