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Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation.

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第一作者： John C,Kraft

第一单位： Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States.

作者： John C,Kraft ^[1] ; Lisa A,McConnachie ^[1] ; Josefin,Koehn ^[1] ; Loren,Kinman ^[1] ; Jianguo,Sun ^[1] ; Ann C,Collier ^[2] ; Carol,Collins ^[1] ; Danny D,Shen ^[1] ; Rodney J Y,Ho ^[3]

作者单位： Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States. ^[1] Department of Medicine, University of Washington, Seattle, WA 98195, United States; Center for AIDS Research, University of Washington, Seattle, WA 98195, United States. ^[2] Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States; Center for AIDS Research, University of Washington, Seattle, WA 98195, United States; Department of Bioengineering, University of Washington, Seattle, WA 98195, United States. Electronic address: rodneyho@uw.edu. ^[3]

关键词 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) (PubChem CID: 94190)1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) (DSPE-mPEG(2000)) (PubChem CID: 406952)Antiretrovirals HIV drug combination treatment Long-acting Lopinavir (PubChem CID: 92727)Lymphatic drug insufficiency Lymphatic targeted drug delivery Mechanism-based pharmacokinetic modeling Ritonavir (PubChem CID: 392622)Tenofovir (PubChem CID: 464205)