T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.-论文-万方医学网

第一作者： Karolina,Woroniecka

第一单位： Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.

作者： Karolina,Woroniecka ^[1] ; Pakawat,Chongsathidkiet ^[2] ; Kristen,Rhodin ^[1] ; Hanna,Kemeny ^[2] ; Cosette,Dechant ^[1] ; S Harrison,Farber ^[1] ; Aladine A,Elsamadicy ^[1] ; Xiuyu,Cui ^[1] ; Shohei,Koyama ^[1] ; Christina,Jackson ^[1] ; Landon J,Hansen ^[3] ; Tanner M,Johanns ^[4] ; Luis,Sanchez-Perez ^[5] ; Vidyalakshmi,Chandramohan ^[6] ; Yen-Rei Andrea,Yu ^[1] ; Darell D,Bigner ^[7] ; Amber,Giles ^[8] ; Patrick,Healy ^[7] ; Glenn,Dranoff ^[9] ; Kent J,Weinhold ^[10] ; Gavin P,Dunn ^[3] ; Peter E,Fecci ^[11]

作者单位： Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. ^[1] Department of Pathology, Duke University Medical Center, Durham, North Carolina. ^[2] Department of Medical Oncology and Cancer Vaccine Center, Dana Farber Cancer Institute, Boston, Massachusetts. ^[3] Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland. ^[4] Department of Pharmacology and Molecular Cancer Biology, Duke University, Durham, North Carolina. ^[5] Division of Medical Oncology, Department of Medicine, Washington University, St. Louis, Missouri. ^[6] Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. ^[7] Department of Medicine, Duke University Medical Center, Durham, North Carolina. ^[8] Neuro-oncology Division, National Institutes of Health, Bethesda, Maryland. ^[9] Department of Biostatistics, Duke University, Durham, North Carolina. ^[10] Department of Surgery, Duke University Medical Center, Durham, North Carolina. ^[11] Department of Neurological Surgery, Center for Human Immunology and Immunotherapy Programs, Washington University, St. Louis, Missouri. ^[12] Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. peter.fecci@duke.edu. ^[13]

主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);女(雌)性(Female);流式细胞术(Flow Cytometry);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);胶质母细胞瘤(Glioblastoma);人类(Humans);干扰素γ(Interferon-gamma);白细胞介素2(Interleukin-2);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);受体, 抗原, T细胞, α-β(Receptors, Antigen, T-Cell, alpha-beta);T淋巴细胞(T-Lymphocytes);肿瘤微环境(Tumor Microenvironment);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1158/1078-0432.CCR-17-1846

PMID 29437767

发布时间 2021-09-08

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T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.

Clinical cancer research

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Clinical cancer research

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T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.

Clinical cancer research

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Clinical cancer research

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