Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an <i>In Vitro</i> Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles.

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第一作者： Thomas,Tu

第一单位： Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany Thomas.Tu@med.uni-heidelberg.de.

作者： Thomas,Tu ^[1] ; Magdalena A,Budzinska ^[2] ; Florian W R,Vondran ^[3] ; Nicholas A,Shackel ^[4] ; Stephan,Urban ^[5]

作者单位： Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany Thomas.Tu@med.uni-heidelberg.de. ^[1] Centenary Institute, The University of Sydney, Sydney, Australia. ^[2] Regenerative Medicine and Experimental Surgery (ReMediES), Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany.;German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany. ^[3] Centenary Institute, The University of Sydney, Sydney, Australia.;South Western Sydney Clinical School, University of New South Wales, Kensington, Australia.;Liverpool Hospital, Gastroenterology, Sydney, Australia. ^[4] Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.;German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany. ^[5]

关键词 HBV DNA integration HBV double-stranded linear DNA Myrcludex B hepatocellular carcinoma inverse nested PCR microhomology-mediated end joining nonhomologous end joining