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Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer.

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第一作者： G,Manzini

第一单位： Department of General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, 89073, Ulm, Germany. giulia.manzini@uniklinik-ulm.de.

作者： G,Manzini ^[1] ; T J,Ettrich ^[2] ; M,Kremer ^[3] ; M,Kornmann ^[3] ; D,Henne-Bruns ^[3] ; D A,Eikema ^[4] ; P,Schlattmann ^[5] ; L C,de Wreede ^[4]

作者单位： Department of General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, 89073, Ulm, Germany. giulia.manzini@uniklinik-ulm.de. ^[1] Department of Internal Medicine, University Hospital of Ulm, Ulm, Germany. ^[2] Department of General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, 89073, Ulm, Germany. ^[3] Department of Medical Statistics and Bioinformatics, Leiden University Medical Center (LUMC), Leiden, Netherlands. ^[4] Department of Medical Statistics, Informatics and Documentation, University of Jena, Jena, Germany. ^[5]

关键词 Distant metastasis (DM)Dynamic prediction Local recurrence (LR)Multi-state model (msm)Rectal cancer (RC)