<i>In Vitro</i> and <i>In Vivo</i> Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.-论文-万方医学网

第一作者： Thomas,Colley

第一单位： Pulmocide Ltd., London, United Kingdom.

作者： Thomas,Colley ^[1] ; Gurpreet,Sehra ^[1] ; Anuradha,Chowdhary ^[2] ; Alexandre,Alanio ^[3] ; Steven L,Kelly ^[4] ; Yasuo,Kizawa ^[5] ; Darius,Armstrong-James ^[6] ; Matthew C,Fisher ^[7] ; Andrew G S,Warrilow ^[4] ; Josie E,Parker ^[4] ; Diane E,Kelly ^[4] ; Genki,Kimura ^[5] ; Yuki,Nishimoto ^[5] ; Mihiro,Sunose ^[8] ; Stuart,Onions ^[8] ; Damien,Crepin ^[8] ; Franz,Lagasse ^[8] ; Matthew,Crittall ^[8] ; Jonathan,Shannon ^[8] ; Matthew,McConville ^[8] ; John,King-Underwood ^[9] ; Alan,Naylor ^[10] ; Stéphane,Bretagne ^[3] ; John,Murray ^[1] ; Kazuhiro,Ito ^[11] ; Pete,Strong ^[1] ; Garth,Rapeport ^[1]

作者单位： Pulmocide Ltd., London, United Kingdom. ^[1] Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. ^[2] Institut Pasteur, CNRS, Molecular Mycology Unit, French National Reference Center for Invasive Mycoses & Antifungals, URA3012, Paris, France.;Paris Diderot, Sorbonne Paris Cité University, Paris, France.;Parasitology-Mycology Laboratory, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France. ^[3] Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, Wales, United Kingdom. ^[4] Laboratory of Physiology and Anatomy, School of Pharmacy, Nihon University, Funabashi, Japan. ^[5] Department of Microbiology, Royal Brompton Hospital, London, United Kingdom.;National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom. ^[6] Department of Infectious Disease Epidemiology, Imperial College School of Public Health, St. Mary's Campus, London, United Kingdom. ^[7] Sygnature Discovery Ltd., Nottingham, United Kingdom. ^[8] CompChem Resource, Ledbury, United Kingdom. ^[9] Alan Naylor Consultancy Ltd., Royston, United Kingdom. ^[10] Pulmocide Ltd., London, United Kingdom kaz@pulmocide.com. ^[11]

医学主题词投药, 鼻内(Administration, Intranasal);动物(Animals);抗真菌药(Antifungal Agents);曲霉菌病(Aspergillosis);烟曲霉菌(Aspergillus fumigatus);氮杂茂类(Azoles);念珠菌属(Candida);隐球菌属(Cryptococcus);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);细胞因子类(Cytokines);抗药性, 真菌(Drug Resistance, Fungal);上皮细胞(Epithelial Cells);麦角固醇(Ergosterol);真菌蛋白质类(Fungal Proteins);半乳糖(Galactose);人类(Humans);菌丝(Hyphae);甘露聚糖类(Mannans);小鼠(Mice);微生物敏感性试验(Microbial Sensitivity Tests);根霉菌属(Rhizopus);三唑类(Triazoles);发癣菌属(Trichophyton)

DOI 10.1128/AAC.01941-17

PMID 29439966

发布时间 2025-05-30

基金项目

MR/R015600/1/MRC_/Medical Research Council/United Kingdom

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<i>In Vitro</i> and <i>In Vivo</i> Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Antimicrobial agents and chemotherapy

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Antimicrobial agents and chemotherapy

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<i>In Vitro</i> and <i>In Vivo</i> Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Antimicrobial agents and chemotherapy

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同项目论文

Antimicrobial agents and chemotherapy

相关期刊

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