High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.

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作者： James G,Burchfield ^[1] ; Melkam A,Kebede ^[2] ; Christopher C,Meoli ^[1] ; Jacqueline,Stöckli ^[1] ; P Tess,Whitworth ^[2] ; Amanda L,Wright ^[1] ; Nolan J,Hoffman ^[2] ; Annabel Y,Minard ^[2] ; Xiuquan,Ma ^[2] ; James R,Krycer ^[1] ; Marin E,Nelson ^[2] ; Shi-Xiong,Tan ^[1] ; Belinda,Yau ^[2] ; Kristen C,Thomas ^[2] ; Natalie K Y,Wee ^[1] ; Ee-Cheng,Khor ^[2] ; Ronaldo F,Enriquez ^[1] ; Bryce,Vissel ^[2] ; Trevor J,Biden ^[1] ; Paul A,Baldock ^[1] ; Kyle L,Hoehn ^[2] ; James,Cantley ^[2] ; Gregory J,Cooney ^[2] ; David E,James ^[2] ; Daniel J,Fazakerley ^[2]

作者单位： From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia. ^[1] Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and. ^[2] Charles Perkins Centre, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia. ^[3] From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia, david.james@sydney.edu.au. ^[4]

关键词 Western diet beta cell (B-cell)bone diabetes glucose metabolism insulin secretion leptin neurodegeneration obesity