Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.

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作者： Kyoko,Hashimoto ^[1] ; Hiroki,Ochi ^[1] ; Satoko,Sunamura ^[1] ; Nobuyoshi,Kosaka ^[2] ; Yo,Mabuchi ^[3] ; Toru,Fukuda ^[4] ; Kenta,Yao ^[1] ; Hiroaki,Kanda ^[5] ; Keisuke,Ae ^[6] ; Atsushi,Okawa ^[7] ; Chihiro,Akazawa ^[3] ; Takahiro,Ochiya ^[2] ; Mitsuru,Futakuchi ^[8] ; Shu,Takeda ^[9] ; Shingo,Sato ^[10]

作者单位： Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan. ^[1] Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 104-0045 Tokyo, Japan. ^[2] Department of Biochemistry and Biophysics, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan. ^[3] Department of Food Science, Tokyo Seiei College, 124-8530 Tokyo, Japan. ^[4] Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, 135-8550 Tokyo, Japan. ^[5] Department of Orthopaedic Oncology, Cancer Institute Ariake Hospital, 135-8550 Tokyo, Japan. ^[6] Department of Orthopaedic Surgery, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan. ^[7] Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 852-8523 Nagasaki, Japan. ^[8] Division of Endocrinology, Toranomon Hospital Endocrine Center, 105-8470 Tokyo, Japan takeda.phy2@tmd.ac.jp satoshin.phy2@tmd.ac.jp. ^[9] Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan; takeda.phy2@tmd.ac.jp satoshin.phy2@tmd.ac.jp. ^[10]

关键词 bone microenvironment cancer-secreted microRNA exosome osteoblastic bone metastasis prostate cancer