TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.-论文-万方医学网

作者： Sanjeev,Mariathasan ^[1] ; Shannon J,Turley ^[1] ; Dorothee,Nickles ^[1] ; Alessandra,Castiglioni ^[1] ; Kobe,Yuen ^[1] ; Yulei,Wang ^[1] ; Edward E,Kadel ^[1] ; Hartmut,Koeppen ^[1] ; Jillian L,Astarita ^[1] ; Rafael,Cubas ^[1] ; Suchit,Jhunjhunwala ^[1] ; Romain,Banchereau ^[1] ; Yagai,Yang ^[1] ; Yinghui,Guan ^[1] ; Cecile,Chalouni ^[1] ; James,Ziai ^[1] ; Yasin,Şenbabaoğlu ^[1] ; Stephen,Santoro ^[1] ; Daniel,Sheinson ^[1] ; Jeffrey,Hung ^[1] ; Jennifer M,Giltnane ^[1] ; Andrew A,Pierce ^[1] ; Kathryn,Mesh ^[1] ; Steve,Lianoglou ^[1] ; Johannes,Riegler ^[1] ; Richard A D,Carano ^[1] ; Pontus,Eriksson ^[2] ; Mattias,Höglund ^[2] ; Loan,Somarriba ^[3] ; Daniel L,Halligan ^[3] ; Michiel S,van der Heijden ^[4] ; Yohann,Loriot ^[5] ; Jonathan E,Rosenberg ^[6] ; Lawrence,Fong ^[7] ; Ira,Mellman ^[1] ; Daniel S,Chen ^[1] ; Marjorie,Green ^[1] ; Christina,Derleth ^[1] ; Gregg D,Fine ^[1] ; Priti S,Hegde ^[1] ; Richard,Bourgon ^[1] ; Thomas,Powles ^[8]

作者单位： Genentech, South San Francisco, California 94080, USA. ^[1] Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Skåne 223 81, Sweden. ^[2] Fios Genomics, Edinburgh EH16 4UX, UK. ^[3] Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. ^[4] Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, 94800 Villejuif, France. ^[5] Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. ^[6] University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94158, USA. ^[7] Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. ^[8]

主题词动物(Animals);抗体(Antibodies);抗体, 单克隆(Antibodies, Monoclonal);抗原, 肿瘤(Antigens, Neoplasm);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);队列研究(Cohort Studies);胶原(Collagen);疾病模型, 动物(Disease Models, Animal);抗药性, 肿瘤(Drug Resistance, Neoplasm);成纤维细胞(Fibroblasts);人类(Humans);免疫疗法(Immunotherapy);小鼠(Mice);突变(Mutation);肿瘤转移(Neoplasm Metastasis);表型(Phenotype);信号传导(Signal Transduction);转化生长因子β(Transforming Growth Factor beta);治疗结果(Treatment Outcome);肿瘤微环境(Tumor Microenvironment);泌尿系肿瘤(Urologic Neoplasms);尿道上皮(Urothelium)

DOI 10.1038/nature25501

PMID 29443960

发布时间 2024-03-28

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Nature

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Nature

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Nature

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