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How many human proteoforms are there?

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作者单位: Department of Biology, ETH Zurich, Zürich, Switzerland. [1] Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA. [2] Department of Chemistry, University of Georgia, Athens, Georgia, USA. [3] Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia. [4] Department of Chemistry, Stanford University, Stanford, California, USA. [5] Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA. [6] Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA. [7] Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA. [8] Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA. [9] Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, and Epigenetics Institute, Philadelphia, Pennsylvania, USA. [10] Department of Cell and Regenerative Biology, Human Proteomics Program, University of Wisconsin-Madison, Madison, Wisconsin, USA. [11] Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA. [12] Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA. [13] Memorial Sloan Kettering Cancer Center, New York, New York, USA. [14] Department of Chemistry, University of Illinois, Urbana, Illinois, USA. [15] Department of Biosciences and Christian Doppler Laboratory for Biosimilar Characterization, University of Salzburg, Salzburg, Austria. [16] Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. [17] The Center for Synthetic Biology, Northwestern University, Evanston, Illinois, USA. [18] Department of Chemistry, Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA. [19] Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [20] Department of Cellular Molecular Pharmacology, University of California, San Francisco, California, USA. [21] Department of Biological Chemistry, University of California, Los Angeles, California, USA. [22] Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden. [23] Department of Genetics, Stanford University, Stanford, California, USA. [24] Department of Genome Sciences, University of Washington, Seattle, Washington, USA. [25] Department of Chemistry, Princeton University, Princeton, New Jersey, USA. [26] Department of Biology, Saint Mary's College of California, Moraga, California, USA. [27] Salk Institute for Biological Studies, Torrey Pines, California, USA. [28] Applied Proteomics, Genentech, Inc., San Francisco, California, USA. [29] Department of Clinical Chemistry/Central Laboratories, University Medical Center Hamburg - Eppendorf, Hamburg, Germany. [30] National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA. [31] Department of Chemistry, Yale University, New Haven, Connecticut, USA. [32] Genome Center of Wisconsin, Madison, Wisconsin, USA. [33] Department of Microbiology, KTH Royal Institute of Technology, Stockholm, Sweden. [34] Cedars Sinai Medical Center, Los Angeles, California, USA. [35] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [36] Department of Pathology, Harvard Medical School and Wyss Institute at Harvard University, Boston, Massachusetts, USA. [37] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [38] Department of Chemistry, University of California, Berkeley, Berkeley, California, USA. [39] Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA. [40] Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [41] Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA. [42]
DOI 10.1038/nchembio.2576
PMID 29443976
发布时间 2023-06-20
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