Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.-论文-万方医学网

作者： Afua A,Akuffo ^[1] ; Aileen Y,Alontaga ^[2] ; Rainer,Metcalf ^[1] ; Matthew S,Beatty ^[3] ; Andreas,Becker ^[1] ; Jessica M,McDaniel ^[4] ; Rebecca S,Hesterberg ^[1] ; William E,Goodheart ^[1] ; Steven,Gunawan ^[2] ; Muhammad,Ayaz ^[1] ; Yan,Yang ^[5] ; Md Rezaul,Karim ^[5] ; Morgan E,Orobello ^[4] ; Kenyon,Daniel ^[5] ; Wayne,Guida ^[1] ; Jeffrey A,Yoder ^[3] ; Anjali M,Rajadhyaksha ^[3] ; Ernst,Schönbrunn ^[6] ; Harshani R,Lawrence ^[7] ; Nicholas J,Lawrence ^[5] ; Pearlie K,Epling-Burnette ^[4]

作者单位： From the Department of Immunology. ^[1] the Cancer Biology Ph.D. Program, University of South Florida, Tampa, Florida 33612. ^[2] the Department of Chemistry and. ^[3] the Chemical Biology Core, and. ^[4] the Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612. ^[5] the Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, and. ^[6] Pediatric Neurology, Pediatrics, Brain and Mind Research Institute, Graduate Program in Neuroscience, Weill Cornell Medicine, Molecular and Developmental Neuroscience Laboratory, New York, New York 10065. ^[7] From the Department of Immunology, Pearlie.Burnette@moffitt.org. ^[8]

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);吖庚因类(Azepines);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);保守序列(Conserved Sequence);CULLIN蛋白质类(Cullin Proteins);人类(Humans);免疫因子类(Immunologic Factors);配体(Ligands);小鼠(Mice);分子探针(Molecular Probes);核蛋白质类(Nuclear Proteins);肽水解酶类(Peptide Hydrolases);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);T淋巴细胞(T-Lymphocytes);沙立度胺(Thalidomide);转录因子(Transcription Factors);三唑类(Triazoles);泛素(Ubiquitin);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1074/jbc.M117.816868

PMID 29449372

发布时间 2021-02-05

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Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

The Journal of biological chemistry

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The Journal of biological chemistry

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Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

The Journal of biological chemistry

相似文献

The Journal of biological chemistry

相关期刊

检索历史清除