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首页> Drug delivery and translational research> pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation.

pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation.

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作者： Syed Ahmed,Shah ^[1] ; Muhammad,Sohail ^[2] ; Muhammad Usman,Minhas ^[3] ; Nisar-Ur-Rehman ^[1] ; Shahzeb,Khan ^[4] ; Zahid,Hussain ^[5] ; Mudassir ^[1] ; Arshad,Mahmood ^[1] ; Mubeen,Kousar ^[1] ; Asif,Mahmood ^[3]

作者单位： Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, 22010, Pakistan. ^[1] Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, 22010, Pakistan. msmarwat@gmail.com. ^[2] Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan. ^[3] Department of Pharmacy, University of Malakand, Lower Dir, KPK, Pakistan. ^[4] Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia. ^[5]

关键词 Acute toxicity Cellulose acetate phthalate Controlled release Gastro-protective Hydrogel

主题词投药, 口服(Administration, Oral);动物(Animals);细胞存活(Cell Survival);纤维素(Cellulose);迟效制剂(Delayed-Action Preparations);药物调剂(Drug Compounding);药物稳定性(Drug Stability);女(雌)性(Female);胃肠道(Gastrointestinal Tract);人类(Humans);水凝胶类(Hydrogels);氢离子浓度(Hydrogen-Ion Concentration);男(雄)性(Male);甲基丙烯酸盐(Methacrylates);小鼠, 近交BALB C(Mice, Inbred BALB C);纳米复合物(Nanocomposites);聚合(Polymerization);片剂(Tablets)

DOI 10.1007/s13346-018-0486-8

PMID 29450805

发布时间 2024-04-11

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Drug delivery and translational research

Drug delivery and translational research

2019年9卷2期

555-577页

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