首页> Proceedings of the National Academy of Sciences of the United States of America> Structure-based discovery of selective positive allosteric modulators of antagonists for the M<sub>2</sub> muscarinic acetylcholine receptor.

Structure-based discovery of selective positive allosteric modulators of antagonists for the M<sub>2</sub> muscarinic acetylcholine receptor.

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第一作者： Magdalena,Korczynska

第一单位： Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.

作者： Magdalena,Korczynska ^[1] ; Mary J,Clark ^[2] ; Celine,Valant ^[3] ; Jun,Xu ^[4] ; Ee Von,Moo ^[3] ; Sabine,Albold ^[3] ; Dahlia R,Weiss ^[1] ; Hayarpi,Torosyan ^[1] ; Weijiao,Huang ^[5] ; Andrew C,Kruse ^[6] ; Brent R,Lyda ^[2] ; Lauren T,May ^[3] ; Jo-Anne,Baltos ^[3] ; Patrick M,Sexton ^[3] ; Brian K,Kobilka ^[7] ; Arthur,Christopoulos ^[8] ; Brian K,Shoichet ^[9] ; Roger K,Sunahara ^[10]

作者单位： Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158. ^[1] Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA 92093. ^[2] Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. ^[3] Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, 100084 Beijing, China. ^[4] Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305. ^[5] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115. ^[6] Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, 100084 Beijing, China.;Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305. ^[7] Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; arthur.christopoulos@monash.edu bshoichet@gmail.com rsunahara@ucsd.edu. ^[8] Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; arthur.christopoulos@monash.edu bshoichet@gmail.com rsunahara@ucsd.edu. ^[9] Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA 92093; arthur.christopoulos@monash.edu bshoichet@gmail.com rsunahara@ucsd.edu. ^[10]

关键词 GPCR PAM antagonist docking structure-based ligand discovery subtype selectivity