First-line anti-tuberculosis drugs induce hepatotoxicity: A novel mechanism based on a urinary metabolomics platform.

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作者： Jun,Cao ^[1] ; Yijun,Mi ^[2] ; Cuilin,Shi ^[3] ; Yicong,Bian ^[4] ; Chenrong,Huang ^[4] ; Zhijian,Ye ^[3] ; Linsheng,Liu ^[5] ; Liyan,Miao ^[6]

作者单位： Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, China; The Fifth People's Hospital of Suzhou, Suzhou 215000, China. ^[1] College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, China. ^[2] The Fifth People's Hospital of Suzhou, Suzhou 215000, China. ^[3] Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. ^[4] Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: linsheng_liu@126.com. ^[5] Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, China. Electronic address: miaolysuzhou@163.com. ^[6]

关键词 First-line anti-tuberculosis drugs Metabolomics Prediction Purine metabolism Pyrazinamide Tuberculosis