Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.

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作者： Charlotte C,Bavley ^[1] ; Richard C,Rice ^[2] ; Delaney K,Fischer ^[3] ; Amanda K,Fakira ^[1] ; Maureen,Byrne ^[3] ; Maria,Kosovsky ^[1] ; Bryant K,Rizzo ^[3] ; Dolores,Del Prete ^[4] ; Armin,Alaedini ^[1] ; Jose A,Morón ^[1] ; Joseph J,Higgins ^[1] ; Luciano,D'Adamio ^[3] ; Anjali M,Rajadhyaksha ^[5]

作者单位： Pediatric Neurology, Department of Pediatrics. ^[1] Feil Family Brain and Mind Research Institute. ^[2] Weill Cornell Autism Research Program, Weill Cornell Medical College, Cornell University, New York, NY 10065. ^[3] Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032. ^[4] Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461. ^[5] Department of Medicine, Columbia University Medical Center, New York, New York 10032, and. ^[6] Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103. ^[7] Pediatric Neurology, Department of Pediatrics, amr2011@med.cornell.edu. ^[8]

关键词 AMPK cereblon excitatory glutamatergic intellectual disability mTOR