Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.
第一作者:
Karim,Labreche
第一单位:
Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, 75013, Paris, France.;Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
作者:
医学主题词
脑肿瘤(Brain Neoplasms);病例对照研究(Case-Control Studies);染色体, 人, 1对(Chromosomes, Human, Pair 1);染色体, 人, 19对(Chromosomes, Human, Pair 19);遗传关联研究(Genetic Association Studies);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);神经胶质瘤(Glioma);人类(Humans);异柠檬酸脱氢酶(Isocitrate Dehydrogenase);突变(Mutation);多态性, 单核苷酸(Polymorphism, Single Nucleotide);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);RNA, 信使(RNA, Messenger);癌蛋白18(Stathmin);末端转移酶端粒(Telomerase)
DOI
10.1007/s00401-018-1825-z
PMID
29460007
发布时间
2025-05-29
- 浏览16
Acta neuropathologica
743-755页
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