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首页> Clinical cancer research : an official journal of the American Association for Cancer Research> Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.

Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.

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作者： Benjamin,Ribba ^[1] ; Christophe,Boetsch ^[2] ; Tapan,Nayak ^[3] ; Hans Peter,Grimm ^[2] ; Jehad,Charo ^[4] ; Stefan,Evers ^[4] ; Christian,Klein ^[5] ; Jean,Tessier ^[3] ; Jean Eric,Charoin ^[2] ; Alex,Phipps ^[6] ; Pavel,Pisa ^[4] ; Volker,Teichgräber ^[4]

作者单位： Pharmaceutical Sciences, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Basel, Switzerland. benjamin.ribba@roche.com. ^[1] Pharmaceutical Sciences, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Basel, Switzerland. ^[2] Translational Imaging Science Oncology, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Basel, Switzerland. ^[3] Translational Medicine Oncology, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Zurich, Switzerland. ^[4] Discovery Oncology, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Zurich, Switzerland. ^[5] Pharmaceutical Sciences, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Welwyn, England. ^[6]

主题词细胞因子类(Cytokines);人类(Humans);免疫因子类(Immunologic Factors);免疫疗法(Immunotherapy);白细胞介素2(Interleukin-2);模型, 生物学(Models, Biological);模型, 理论(Models, Theoretical);分子显像(Molecular Imaging);肿瘤(Neoplasms);预后(Prognosis);受体, 白细胞介素2(Receptors, Interleukin-2);治疗结果(Treatment Outcome)

DOI 10.1158/1078-0432.CCR-17-2953

PMID 29463551

发布时间 2019-12-20

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Clinical cancer research : an official journal of the American Association for Cancer Research

Clinical cancer research

2018年24卷14期

3325-3333页

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Clinical cancer research : an official journal of the American Association for Cancer Research

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Clinical cancer research

2018年24卷14期

3325-3333页

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