Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.

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作者： Gangqing,Hu ^[1] ; Kairong,Cui ^[2] ; Difeng,Fang ^[3] ; Satoshi,Hirose ^[4] ; Xun,Wang ^[4] ; Darawalee,Wangsa ^[5] ; Wenfei,Jin ^[2] ; Thomas,Ried ^[5] ; Pentao,Liu ^[6] ; Jinfang,Zhu ^[3] ; Ellen V,Rothenberg ^[7] ; Keji,Zhao ^[8]

作者单位： Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: hug21@nhlbi.nih.gov. ^[1] Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. ^[2] Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. ^[3] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. ^[4] Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. ^[5] Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK. ^[6] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: evroth@its.caltech.edu. ^[7] Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: zhaok@nhlbi.nih.gov. ^[8]

关键词 4D nucleome AB compartment conversion AD connectivity BCL11B DNase hypersensitive sites T cell development chromatin conformation lineage commitment