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首页> Frontiers in immunology> Eliminating Factor H-Binding Activity of <i>Borrelia burgdorferi</i> CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine.

Eliminating Factor H-Binding Activity of <i>Borrelia burgdorferi</i> CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine.

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作者： Ashley L,Marcinkiewicz ^[1] ; Ilva,Lieknina ^[2] ; Svetlana,Kotelovica ^[2] ; Xiuli,Yang ^[3] ; Peter,Kraiczy ^[4] ; Utpal,Pal ^[3] ; Yi-Pin,Lin ^[5] ; Kaspars,Tars ^[6]

作者单位： Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, United States. ^[1] Latvian Biomedical Research and Study Centre, Riga, Latvia. ^[2] Department of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, United States. ^[3] Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt am Main, Germany. ^[4] Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, United States.;Department of Biomedical Science, State University of New York at Albany, Albany, NY, United States. ^[5] Latvian Biomedical Research and Study Centre, Riga, Latvia.;Faculty of Biology, University of Latvia, Riga, Latvia. ^[6]

关键词 Borrelia CspZ Lyme disease factor H vaccine virus-like particles

主题词动物(Animals);抗体, 细菌(Antibodies, Bacterial);细菌外膜蛋白质类(Bacterial Outer Membrane Proteins);伯氏疏螺旋体(Borrelia burgdorferi);补体因子H(Complement Factor H);免疫法, 被动(Immunization, Passive);莱姆病(Lyme Disease);莱姆病菌苗(Lyme Disease Vaccines);男(雄)性(Male);小鼠(Mice);血清杀菌抗体检测(Serum Bactericidal Antibody Assay);疫苗, 病毒样颗粒(Vaccines, Virus-Like Particle)

DOI 10.3389/fimmu.2018.00181

PMID 29472926

发布时间 2024-07-20

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Frontiers in immunology

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