CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.

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作者： Jianfeng,Wu ^[1] ; Sirui,Yang ^[2] ; Di,Yu ^[3] ; Wenjing,Gao ^[1] ; Xianjun,Liu ^[1] ; Kun,Zhang ^[1] ; Xueqi,Fu ^[4] ; Wanguo,Bao ^[5] ; Kaiyu,Zhang ^[6] ; Jiaao,Yu ^[6] ; Liankun,Sun ^[7] ; Shaofeng,Wang ^[2]

作者单位： The Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, China. ^[1] College of Basic Medicine, The Jilin University, Changchun, China. ^[2] The Institute of Pediatrics, The First Hospital of Jilin University, Changchun, China. ^[3] The Center of Research, The Second Hospital of Jilin University, Changchun, China. ^[4] The College of Life Sciences, The Jilin University, Changchun, China. ^[5] Department of Infectious Diseases, The First Hospital of Jilin University, Changchun, China. ^[6] Department of Burn Surgery, The First Hospital of Jilin University, Changchun, China. ^[7] The Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, China. shaofengwang@jlu.edu.cn. ^[8] The Institute of Pediatrics, The First Hospital of Jilin University, Changchun, China. shaofengwang@jlu.edu.cn. ^[9]

主题词自身免疫疾病(Autoimmune Diseases);HEK293细胞(HEK293 Cells);人类(Humans);突变(Mutation);多态性, 单核苷酸(Polymorphism, Single Nucleotide);受体, 白细胞介素(Receptors, Interleukin)

DOI 10.1038/s41435-018-0011-6

PMID 29483615

发布时间 2022-04-15

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