换一批Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
第一作者：
Jinxing,Hu
第一单位：
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.
作者：
医学主题词
抗肿瘤药(Antineoplastic Agents);苯衍生物(Benzene Derivatives);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物发现(Drug Discovery);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);HT29细胞(HT29 Cells);人类(Humans);分子结构(Molecular Structure);突变(Mutation);蛋白激酶抑制剂(Protein Kinase Inhibitors);嘌呤类(Purines);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.bmc.2018.02.029
PMID
29486953
发布时间
2018-12-02
- 浏览9
Bioorganic & medicinal chemistry
1810-1822页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
