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Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.

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第一作者： Karl P,Hodel

第一单位： Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, United States.

作者： Karl P,Hodel ^[1] ; Richard,de Borja ^[2] ; Erin E,Henninger ^[1] ; Brittany B,Campbell ^[3] ; Nathan,Ungerleider ^[4] ; Nicholas,Light ^[2] ; Tong,Wu ^[4] ; Kimberly G,LeCompte ^[1] ; A Yasemin,Goksenin ^[1] ; Bruce A,Bunnell ^[5] ; Uri,Tabori ^[6] ; Adam,Shlien ^[7] ; Zachary F,Pursell ^[8]

作者单位： Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, United States. ^[1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada. ^[2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.;Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada. ^[3] Department of Pathology, Tulane University School of Medicine, New Orleans, United States. ^[4] Department of Pharmacology, Tulane University School of Medicine, New Orleans, United States.;Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, United States. ^[5] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.;The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.;Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada. ^[6] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.;Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.;Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. ^[7] Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, United States.;Tulane Cancer Center, Tulane University School of Medicine, New Orleans, United States. ^[8]

关键词 DNA Polymerase DNA Replication Genome Stability Mutagenesis biochemistry cancer biology chemical biology human

医学主题词细胞系, 肿瘤(Cell Line, Tumor);结直肠肿瘤(Colorectal Neoplasms);DNA错配修复(DNA Mismatch Repair);DNA聚合酶Ⅱ(DNA Polymerase II);人类(Humans)

DOI 10.7554/eLife.32692

PMID 29488881

发布时间 2022-04-06

基金项目

NIH P20 RR020152/RR/NCRR NIH HHS/United States NIH R00 ES016780/ES/NIEHS NIH HHS/United States R01 ES028271/ES/NIEHS NIH HHS/United States R00 ES016780/ES/NIEHS NIH HHS/United States NIH R56ES026821/ES/NIEHS NIH HHS/United States NIH R01ES028271/ES/NIEHS NIH HHS/United States P20 RR020152/RR/NCRR NIH HHS/United States P51 OD011104/OD/NIH HHS/United States R56 ES026821/ES/NIEHS NIH HHS/United States

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