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A minimal RNA ligand for potent RIG-I activation in living mice.

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第一作者： Melissa M,Linehan

第一单位： Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

作者： Melissa M,Linehan ^[1] ; Thayne H,Dickey ^[2] ; Emanuela S,Molinari ^[2] ; Megan E,Fitzgerald ^[2] ; Olga,Potapova ^[2] ; Akiko,Iwasaki ^[3] ; Anna M,Pyle ^[4]

作者单位： Department of Immunobiology, Yale University, New Haven, CT 06520, USA. ^[1] Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. ^[2] Department of Immunobiology, Yale University, New Haven, CT 06520, USA.;Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.;Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. ^[3] Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.;Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. ^[4]

医学主题词动物(Animals);基因表达调控(Gene Expression Regulation);HEK293细胞(HEK293 Cells);人类(Humans);干扰素类(Interferons);配体(Ligands);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);核酸构象(Nucleic Acid Conformation);磷酰化(Phosphorylation);聚肌胞苷酸(Poly I-C);RNA(RNA);受体, 免疫(Receptors, Immunologic)

DOI 10.1126/sciadv.1701854

PMID 29492454

发布时间 2024-03-13

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