A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3.

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第一作者： Janna,Bednenko

第一单位： a TetraGenetics Inc , Arlington , Massachusetts , USA.

作者： Janna,Bednenko ^[1] ; Rian,Harriman ^[2] ; Lore,Mariën ^[3] ; Hai M,Nguyen ^[4] ; Alka,Agrawal ^[1] ; Ashot,Papoyan ^[1] ; Yelena,Bisharyan ^[1] ; Joanna,Cardarelli ^[1] ; Donna,Cassidy-Hanley ^[5] ; Ted,Clark ^[1] ; Darlene,Pedersen ^[5] ; Yasmina,Abdiche ^[6] ; William,Harriman ^[7] ; Bas,van der Woning ^[6] ; Hans,de Haard ^[3] ; Ellen,Collarini ^[3] ; Heike,Wulff ^[6] ; Paul,Colussi ^[4]

作者单位： a TetraGenetics Inc , Arlington , Massachusetts , USA. ^[1] b Department of Immunology , Crystal Bioscience , Emeryville , California , USA. ^[2] c argenx , Zwijnaarde , Belgium. ^[3] d Department of Pharmacology , University of California , Davis , California , USA. ^[4] e Department of Immunology and Microbiology , Cornell University , Ithaca , New York , USA. ^[5] f Ligand Pharmaceuticals , San Diego, California , USA. ^[6] g Carterra Inc , Salt Lake City , Utah , USA. ^[7]

关键词 Kv1.3 Tetrahymena antibody voltage-gated ion channel

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);骆驼, 新大陆(Camelids, New World);鸡(Chickens);药物发现(Drug Discovery);人类(Humans);Kv1.3钾通道(Kv1.3 Potassium Channel);重组蛋白质类(Recombinant Proteins);嗜热四膜虫(Tetrahymena thermophila)

DOI 10.1080/19420862.2018.1445451

PMID 29494279

发布时间 2019-08-12

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A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3.

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A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3.

mAbs

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mAbs

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