Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway.

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第一作者： Daqian,Yang

第一单位： College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

作者： Daqian,Yang ^[1] ; Huijie,Jiang ^[2] ; Jingjing,Lu ^[1] ; Yueying,Lv ^[1] ; Ruiqi,Baiyun ^[3] ; Siyu,Li ^[3] ; Biying,Liu ^[1] ; Zhanjun,Lv ^[4] ; Zhigang,Zhang ^[5]

作者单位： College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. ^[1] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. ^[2] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China. ^[3] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. ^[4] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. Electronic address: zhangzhigang@neau.edu.cn. ^[5]

关键词 Grape seed proanthocyanidin extract Hepatic fatty acids metabolism Lead PPARα signaling pathway Transcriptional regulation