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首页> Neuropharmacology> Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons.

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons.

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作者： Louise,Ritchie ^[1] ; Rothwell,Tate ^[1] ; Luke H,Chamberlain ^[1] ; Graham,Robertson ^[2] ; Michele,Zagnoni ^[2] ; Teresa,Sposito ^[3] ; Selina,Wray ^[3] ; John A,Wright ^[4] ; Clare E,Bryant ^[4] ; Nicholas J,Gay ^[5] ; Trevor J,Bushell ^[6]

作者单位： Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. ^[1] Centre for Microsystems and Photonics, Electronic and Electrical Engineering, University of Strathclyde, Glasgow, G1 1XW, UK. ^[2] Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, UK. ^[3] Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. ^[4] Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK. ^[5] Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. Electronic address: trevor.bushell@strath.ac.uk. ^[6]

关键词 Action potential Na(+) channel Neuron Poly I:C TLR3 TRIF iPSC-derived neuron mEPSCs

主题词动作电位(Action Potentials);衔接蛋白质类, 膜泡运输(Adaptor Proteins, Vesicular Transport);动物(Animals);大脑皮质(Cerebral Cortex);剂量效应关系, 药物(Dose-Response Relationship, Drug);兴奋性突触后电位(Excitatory Postsynaptic Potentials);海马(Hippocampus);人类(Humans);微突触后电位(Miniature Postsynaptic Potentials);神经元(Neurons);聚肌胞苷酸(Poly I-C);大鼠(Rats);大鼠, 转基因(Rats, Transgenic);受体, 谷氨酸(Receptors, Glutamate);信号传导(Signal Transduction);钠通道阻滞剂(Sodium Channel Blockers);突触传递(Synaptic Transmission);Toll样受体3(Toll-Like Receptor 3)

DOI 10.1016/j.neuropharm.2018.02.025

PMID 29505789

发布时间 2022-07-22

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