首页> Journal of medicinal chemistry> Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.

Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.

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第一作者： Mitsunori,Kono

第一单位： Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1 Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan.

作者： Mitsunori,Kono ^[1] ; Atsuko,Ochida ^[1] ; Tsuneo,Oda ^[1] ; Takashi,Imada ^[1] ; Yoshihiro,Banno ^[1] ; Naohiro,Taya ^[1] ; Shinichi,Masada ^[1] ; Tetsuji,Kawamoto ^[1] ; Kazuko,Yonemori ^[1] ; Yoshi,Nara ^[1] ; Yoshiyuki,Fukase ^[1] ; Tomoya,Yukawa ^[1] ; Hidekazu,Tokuhara ^[1] ; Robert,Skene ^[2] ; Bi-Ching,Sang ^[2] ; Isaac D,Hoffman ^[2] ; Gyorgy P,Snell ^[2] ; Keiko,Uga ^[1] ; Akira,Shibata ^[1] ; Keiko,Igaki ^[1] ; Yoshiki,Nakamura ^[1] ; Hideyuki,Nakagawa ^[1] ; Noboru,Tsuchimori ^[1] ; Masashi,Yamasaki ^[1] ; Junya,Shirai ^[1] ; Satoshi,Yamamoto ^[1]

作者单位： Pharmaceutical Research Division , Takeda Pharmaceutical Company Limited , 26-1 Muraoka-Higashi 2-chome , Fujisawa , Kanagawa 251-8555 , Japan. ^[1] Takeda California , 10410 Science Center Drive , San Diego , California 92121 , United States. ^[2]