首页> Nature communications> Genome-wide analysis yields new loci associating with aortic valve stenosis.

Genome-wide analysis yields new loci associating with aortic valve stenosis.

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第一作者： Anna,Helgadottir

第一单位： deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. anna.helgadottir@decode.is.

作者： Anna,Helgadottir ^[1] ; Gudmar,Thorleifsson ^[2] ; Solveig,Gretarsdottir ^[2] ; Olafur A,Stefansson ^[2] ; Vinicius,Tragante ^[2] ; Rosa B,Thorolfsdottir ^[2] ; Ingileif,Jonsdottir ^[3] ; Thorsteinn,Bjornsson ^[2] ; Valgerdur,Steinthorsdottir ^[2] ; Niek,Verweij ^[4] ; Jonas B,Nielsen ^[5] ; Wei,Zhou ^[6] ; Lasse,Folkersen ^[7] ; Andreas,Martinsson ^[8] ; Mahyar,Heydarpour ^[9] ; Siddharth,Prakash ^[10] ; Gylfi,Oskarsson ^[11] ; Tomas,Gudbjartsson ^[12] ; Arnar,Geirsson ^[13] ; Isleifur,Olafsson ^[14] ; Emil L,Sigurdsson ^[15] ; Peter,Almgren ^[16] ; Olle,Melander ^[16] ; Anders,Franco-Cereceda ^[17] ; Anders,Hamsten ^[18] ; Lars,Fritsche ^[19] ; Maoxuan,Lin ^[5] ; Bo,Yang ^[20] ; Whitney,Hornsby ^[21] ; Dongchuan,Guo ^[10] ; Chad M,Brummett ^[22] ; Gonçalo,Abecasis ^[23] ; Michael,Mathis ^[22] ; Dianna,Milewicz ^[24] ; Simon C,Body ^[9] ; Per,Eriksson ^[18] ; Cristen J,Willer ^[25] ; Kristian,Hveem ^[19] ; Christopher,Newton-Cheh ^[26] ; J Gustav,Smith ^[8] ; Ragnar,Danielsen ^[27] ; Gudmundur,Thorgeirsson ^[28] ; Unnur,Thorsteinsdottir ^[3] ; Daniel F,Gudbjartsson ^[29] ; Hilma,Holm ^[2] ; Kari,Stefansson ^[30]

作者单位： deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. anna.helgadottir@decode.is. ^[1] deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. ^[2] deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland. ^[3] Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands.;Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA. ^[4] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109, MI, USA. ^[5] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, 48109, MI, USA. ^[6] Cardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden.;Department of Bioinformatics, Technical University of Denmark, Copenhagen, 2800, Denmark. ^[7] Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, 22185, Sweden. ^[8] Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. ^[9] Department of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA. ^[10] Childrens Hospital, Landspitali National University Hospital of Iceland, Reykjavik, 101, Iceland. ^[11] Department of Surgery and Cardiothoracic Surgery, Landspitali National University Hospital, Reykjavik, 101, Iceland. ^[12] Section of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, 06510, CT, USA. ^[13] Department of Clinical Biochemistry, Landspitali National University Hospital, Reykjavik, 101, Iceland. ^[14] Heilsugaeslan Solvangi, Hafnarfjördur, 220, Iceland.;Department of Family Medicine, University of Iceland, Reykjavik, 101, Iceland. ^[15] Department of Clinical Sciences, Lund University, Malmö, 22185, Sweden.;Department of Internal Medicine, Skåne University Hospital, Malmö, 22185, Sweden. ^[16] Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden. ^[17] Cardiovascular Medicine Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, 17176, Sweden. ^[18] HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7491, Norway.;K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, 7491, Norway. ^[19] Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI, 48105, USA.;Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA. ^[20] Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA. ^[21] Department of Anesthesiology, University of Michigan, Ann Arbor, MI, 48105, USA. ^[22] Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA. ^[23] Department of Internal Medicine, Division of Medical Genetics, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.;Medicine Services, Texas Heart Institute, St. Luke's Episcopal Hospital, Houston, TX, 77030, USA. ^[24] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109, MI, USA.;Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, 48109, MI, USA.;Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, 48109, USA.;Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA. ^[25] Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.;Massachusetts General Hospital, Harvard Medical School, Broad Institute of Harvard and MIT, Boston, MA, 02114, USA.;Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA. ^[26] Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.;Department of Internal Medicine, Division of Cardiology, Landspitali National University Hospital of Iceland, Reykjavik, 101, Iceland. ^[27] deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.;Department of Internal Medicine, Division of Cardiology, Landspitali National University Hospital of Iceland, Reykjavik, 101, Iceland. ^[28] deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.;School of Engineering and Natural Sciences, University of Iceland, Reykjavik, 101, Iceland. ^[29] deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland. kstefans@decode.is.;Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland. kstefans@decode.is. ^[30]