Evaluation of MLH1 variants of unclear significance.

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作者： Nicole,Köger ^[1] ; Lea,Paulsen ^[1] ; Francisco,López-Kostner ^[2] ; Adriana,Della Valle ^[3] ; Carlos Alberto,Vaccaro ^[4] ; Edenir Inêz,Palmero ^[5] ; Karin,Alvarez ^[6] ; Carlos,Sarroca ^[2] ; Florencia,Neffa ^[3] ; Pablo German,Kalfayan ^[3] ; Maria Laura,Gonzalez ^[4] ; Benedito Mauro,Rossi ^[4] ; Rui Manuel,Reis ^[7] ; Angela,Brieger ^[1] ; Stefan,Zeuzem ^[8] ; Inga,Hinrichsen ^[9] ; Mev,Dominguez-Valentin ^[1] ; Guido,Plotz ^[1]

作者单位： Biomedizinisches Forschungslabor, Medizinische Klinik 1, Universitätsklinik Frankfurt, Frankfurt, Germany. ^[1] Laboratorio de Oncología y Genética Molecular, Clínica Los Condes, Santiago, Chile. ^[2] Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay. ^[3] Hereditary Cancer Program (PROCANHE), Hospital Italiano, Buenos Aires, Argentina. ^[4] Barretos Cancer Hospital, Molecular Oncology Research Center, Barretos, São Paulo, Brazil. ^[5] Barretos School of Health Sciences-FACISB, Barretos, São Paulo, Brazil. ^[6] Hospital Sirio Libanes, Sao Paulo, Brazil. ^[7] Life and Health Sciences Q5 753 Research Institute (ICVS), Health Sciences School, University of Minho, Braga, 754, Portugal. ^[8] ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, 755, Portugal. ^[9] Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. ^[10]

关键词 Lynch syndrome classification mlh1 pathogenicity variant of uncertain significance